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Anxiety and Stress Relief: What are the Most Effective Nootropics?

Medical data indicates that anxiety has rapidly become one of the most widespread problems faced by a large number of people worldwide. Although not everyone has experienced anxiety-related disorders which are diagnosed medically, almost every individual has felt mildly anxious for some time at some stage of their life. In addition to adversely affecting the individual both physically and mentally, the daily routine of a person may be disrupted by anxiety. Anxiety can make a person feel both depressed and lethargic, and also can cause overeating resulting in weight gain.

What Is Anxiety And Why It’s Harmful

Our world is changing at a rapid pace. Many people have very busy schedules, including having to complete large numbers of tasks and activities as part of their normal routine. Anxiety can adhere to one’s schedule and become a part of everyday life. When stress levels become extremely high, people can tend to waste too much time worrying rather than actually doing. Most people associate the word Anxiety with being chaotic, but that’s not entirely accurate. According to the widely used Merriam-Webster English dictionary, anxiety is the feeling of worry, unease, or nervousness about uncertain outcomes. Anxiety involves worrying about events which will take place in the future. Some people who experience anxiety often feel unsafe, because their predominant emotion is fear.

NootropicsStudies have indicated that the main cause of anxiety is the deficiency of dopamine and GABA (gamma-aminobutyric acid) in the brain. Anxiety also can often result in some physical changes in the body. Aside from negative feelings and thoughts, an anxious person may feel like their heart is racing, have shaky limbs, and experience sweating. People of all ages experience anxiety, anywhere from a 5-year-old child to a 65-year-old senior. Some common situations where people become anxious are when they have to write a test, interview for a job, or speak in public in front of a large number people. In some extreme cases, even just being present in a crowded room with a large number of people can trigger anxiety.

Experiencing symptoms of anxiety for an extended period of time can really take a toll on your quality of life. Though anxiety is a disorder that affects mental health, it can also adversely affect the physical health of a person. Unfortunately, anxiety has become a part of life for some people. For example, anxiety can occur from being around a crowd of unknown people, or even from receiving a phone call that was not previously anticipated.

In the short term, symptoms of anxiety usually start with increases in heart and pulse rates, and sometimes hyperventilation can occur. Anxiety may also increase the quantity of blood flow into the brain, causing feelings of lightheadedness and nausea. All in all, having an anxiety-related disorder can make it difficult to lead a normal life, negatively impact a person’s social life, and relationships with family members.

The different types of anxiety disorders can be classified into:

  • Phobia
  • Panic Disorder
  • Social Anxiety Disorder
  • Generalized Anxiety Disorder

Its normal for anyone to becomes anxious or feel nervous sometimes. However, some people experience anxiousness more often than not and this can affect their way of looking at life. You should be considerate whenever dealing with an anxious person. If they are a friend or family member, try and help them seek treatment. If left untreated anxiety can lead to very severe depression and thoughts of suicide.

Nootropics and Anxiety

The availability of nootropic drugs has allowed many people to help decrease levels of anxiety and stress. One of the main advantages of using nootropic drugs compared to prescription pills for anxiety treatment is that they do not have as many side effects. Often many prescription medications used to treat anxiety have side-effects that can outweigh the good, such as decreased motivation, and fatigue. Some people even believe that prescription medication can increase anxiety levels, and some have addictive side-effects. This is why many patients have chosen to use nootropic substances to keep their anxiety levels at bay while remaining motivated to live a fulfilling life.

Nootropics are most commonly known for:

  • Enhancing learning capacity and memory.
  • Protecting the brain from the damage caused by toxic chemicals and physical attacks.
  • Improving neuronal firing control in the brain.
  • Ensuring that brain functioning isn’t affected even under hostile conditions.
  • Having low toxic levels and side effects.

The current list of nootropic substances available can be classified into three major categories described below.

Types of Nootropics
Racetams Stimulants Nutraceuticals
These influence acetylcholine in the brain which is directly connected to the memory, mental agility, mood, and focus. They can also increase the brain’s capacity to learn new things. These help to make users feel more mentally alert and can make it easier to concentrate.   These are basically food and food ingredients which may contain small amounts of racetams, stimulants, and other nootropics. They are of course safe for consumption.

Nootropics have an advantage over prescription medications used for treating anxiety because they are safer. Unlike prescription pills, the possibility of addiction is far lower with nootropics.

NootropicsTherefore discerning users should find that nootropics are the more optimal way to deal with stress.

Individual anxiety disorder is a serious issue and one should always consult a professional before taking medication. Nootropics are also beneficial for milder instances of anxiety since they treat it using neurochemicals. Some nootropic drugs increase the production of GABA and utilize it more efficiently. GABA is the inhibitory neurotransmitter which helps to keep the brain relaxed and remain tranquil, while at the same time reducing central nervous system stimulation. Other nootropics alter the way the human brain processes dopamine and serotonin. What all of these substances have in common is their ability to help keep the brain calm and relaxed.

Research indicates that the use of nootropics can significantly benefit the life of anxious people since they help to balance the production of neurotransmitters and promote normal blood flow to the brain. They also alter brainwaves, enhance brain cell production and protect cells from damage. Consuming nootropics regularly will help a person who is experiencing anxiety deal with the mental and physical stress. Nootropic users may handle stress better, be able to think more clearly, and their memory and reflexes may be improved.

Best Nootropics for Anxiety

Individuals experiencing types of social anxiety that make dealing with crowds unpleasant, or that have performance related anxiety, will find that there are many nootropics which can help them relax and increase confidence. Let’s get into some of the most popular and effective nootropics for dealing with anxiety.


Aniracetam is considered to be the most effective nootropic for managing anxiety disorder. Experts recommend that individuals start with aniracetam if they have never used any form of nootropic before. Aniracetam can lower stress levels without adverse side effects such as sedation. A majority of users have reported a reduction in both their anxiety and stress levels while using aniracetam and also report noticeable improvements in focus.

Aniracetam was originally formulated by Hoffman La-Roche, a world-famous chemist in the 1970’s. Aniracetam is a member of the racetam family. Aniracetam is considered to be slightly more potent than its cousin piracetam.

The exact method of how aniracetam is able to lower stress levels has not yet been fully determined. However, chemists claim that the substance acts on the human body in a way similar to other supplements found in the racetam family.

NootropicsAMPA plays an important role in both memory and learning and research indicates that aniracetam stimulates the receptor sites of AMPA. Aniracetam is believed to be effective in reducing anxiety because of the fact that D3 and D2 dopamine receptors become activated after the supplement is consumed.

Some of the benefits of using aniracetam supplements are:

  • Aniracetam helps to reduce both anxiety and stress.
  • Aniracetam enhances memory and learning capacity.
  • Aniracetam makes the user more perceptive.

The recommended daily dosage of aniracetam is 1-2 grams, this should greatly reduce the anxiety most patients experience as part of their daily life. The consumption of this drug should also keep their thoughts sharp and focused. Since aniracetam isn’t addictive and does not have any adverse side effects, it is widely considered one of the best nootropics for dealing with social anxiety.


Phenibut is also a popular nootropic for managing different kinds anxiety but is specifically well-suited for alleviating social anxiety. As previously stated, the GABA chemical found in the human brain helps relaxation to a large degree. Interestingly, phenibut includes a modified version of the GABA molecule.

Using 500-1000 mg of phenibut regularly can greatly help to alleviate anxiety. However, a major disadvantage of using phenibut is that it may take hours to become effective after being consumed. Users have to be careful of this and ensure that they do not take additional doses during the same time period. Even though effects may take longer to begin taking place, once they do start to kick in the supplement will be effective for a period of 24 hours.

There are several adverse side effects associated with the abuse or frequent usage of phenibut. So users should limit consuming phenibut to once or twice a week maximum.

The use of phenibut may cause the following benefits:

  • The user may become relaxed sleep more comfortably at night.
  • Reduced anxiety and stress.
  • Improved overall mood.

L – Theanine

L-Theanine is an amino acid found in tea. This ingredient is the reason why people tend to feel focused and calm after drinking tea. People that experience anxiety will be unable to get the amount of L-Theanine they require to reduce anxiety by consuming a single cup, and it is not feasible to consume such a large number of cups required to produce the appropriate amount of L-Theanine.

Hence, the L-Theanine ingredient is extracted and manufactured by combining certain chemicals and then sold to be taken as a supplement. L-Theanine is able to reduce anxiety by mimicking glutamate, a natural amino acid in the body. It also helps to improve the levels of dopamine in the human brain. It’s important to mention that anxiety can be treated by taking this supplement without causing sedation, or any other adverse effects.

Many users choose to combine L-Theanine with coffee.  L-Theanine combines with the caffeine in coffee helping the user feel focused and relaxed. By combining coffee alongside L-Theanine, a user can enjoy the stimulating benefit of caffeine while at the same time reducing or eliminating entirely, side effects like jitters.

In addition to anxiety reduction, L-Theanine has a large number of other benefits which include:

  • Improving receptiveness and memory.
  • Reduce physical and mental stress.
  • Amazingly powerful when used with coffee.


Noopept is considered to be one of the most potent nootropics available and is also a very effective nootropic for treating anxiety. Noopept stimulates the psyche and enhances the cognitive abilities of its users. Noopept is highly recommended for individuals working in environments that are mentally demanding. The effects of this drug act on the body and mind, within minutes of being consumed.


Inositol is a substance which has been recently introduced and become very popular. Its molecules are found naturally in citrus fruits and other foods. It is structurally similar to sugar, however, when ingested in the body it behaves like a vitamin. Vendors even sometimes incorrectly label this substance as a type of vitamin B supplement.

In a manner quite similar to vitamins, inositol acts on a number of organs in the human body. For example, the substance is used to improve the fertility of women, helps regulate the blood glucose levels in pre diabetics and diabetics, and also has a number of neurological benefits making it very popular within the nootropics sector. Arguably one of the most researched and important benefits that inositol offers is its ability to neurologically treat anxiety and other related disorders.

NootropicsSome of the first researchers that investigated the effectiveness of myo-inositol for treating anxiety noted that the supplement significantly helped patients whose anxiety was mainly caused by stress. This indicates that inositol works best on the mechanisms in the body that balance responses to stress. Researchers have tried to find out how inositol can be utilized for combatting anxiety, especially its response to stress which causes havoc in the lives of many people worldwide.

In the year 2001, a clinical trial was conducted which found that a high dose of 18g of inositol daily was as effective in reducing anxiety symptoms as using 150 mg of fluvoxamine (a popular pharmaceutical medication used for treating anxiety). These significant results again highlight the benefit of consuming inositol as a treatment for anxiety.

Although inositol is found in a large number of food products, the amount of inositol necessary for treating anxiety as proved by research results is far higher than what can be obtained from food alone. So it is recommended that a supplement containing highly concentrated inositol amounts be consumed by anxiety sufferers, instead of relying exclusively on natural food sources.

Though the recommended dosage of inositol for treating neurological disorders like depression or anxiety is between 14-18 grams daily, improvement has been noted in doses as low as 6g daily. The supplement can be purchased as a powder, or as capsules. The powder is popularly added to smoothies and other drinks.

Inositol is an extremely safe supplement. This fact has been proved in both clinical trials and animal toxicity studies carried out on humans with doses as high as 30g daily. In all of these trials and studies, no complications were observed other than some cases of mild discomfort in the digestive system. Even these rare problems can be eliminated by reducing the supplement dose as soon as some discomfort or pain is experienced.

So to summarize, inositol is a very effective and safe supplement for treating anxiety symptoms, especially if the anxiety is caused by stressful activities or events.


Picamilon is unique as it boots mental energy levels and improves cognitive functioning while at the same time lowering stress and anxiety levels. The energizing and relaxing effects of this nootropic improve the productivity of its users. It is the recommended supplement for individuals who wish to think quickly and clearly while under stress. For example, students preparing for exams. Picamilon is also a very effective tool for dealing with social anxiety. It combines calming and energizing effects and additionally, this supplement can improve sleep quality and helps to lower blood pressure levels. The average daily dosage for Picamilon users varies from 50 mg to 400 mg. Though Picamilon is a comparatively safe supplement, some side effects may be noticed. Low blood pressure and minor headaches are the most frequently noticed side effects and some people may be allergic to the drug.

Lemon Balm

Lemon Balm is very effective for reducing panic attacks and helps to relieve stress. This supplement ensures that levels of GABA in the human brain are normal and helps to regulate mood. This nootropic is also an extremely effective antidepressant and antioxidant. Consuming lemon balm regularly can help to prevent damage to brain cells. Lemon Balm is a very useful natural nootropic for treating problems like depression, irritability, and anxiety while improving focus, concentration, memory, and learning. This substance is also known to have little to no known side effects.


Ginseng is a nootropic derived from a herb known for naturally improving brain power. Consuming this supplement ensures that new blood vessels are produced within the brain, leading to improved blood circulation. Neurotransmitter activity is also enhanced and an increase in the synthesis of proteins improves many factors such as; alertness levels, cognition, memory, and mental fatigue. Ginseng is used as a cardiotonic, and it has both hypoglycemic and hemostatic effects.


Ashwagandha is regarded as one of the most potent ayurveda medicines. This herb is found naturally in Pakistan, Sri Lanka, and India. Ashwagandha is extremely effective for alleviating symptoms of depression and anxiety. The chemicals in this herb activate the GABA-A receptors in the body, (the mechanism which has a sleep-inducing and anxiolytic effect).

Ashwagandha also reduces levels of cortisol, (the stress hormone) and thus reduces anxiety and depression. It also helps in regenerating synapses, axons, and dendrites and restores neural pathways required for better memory. Ashwagandha is a safe nootropic that helps users deal with stress effectively leading to a happier and more relaxed life.


Although anxiety has become a large part of modern life, there is no reason why is a person should quietly endure its adverse effects. By consuming one, or a combination of the many anxiety related nootropics mentioned in this article, you can begin to take control of your life and eliminate unpleasant feelings of anxiety. In addition to reducing anxiety, sluggishness or mental fatigue, these supplements make users feel more motivated and focused. It is advised to adhere to strict guidelines when using these drugs to maximize their benefits. When nootropic supplements are used in an optimal manner, they can help users lead a happy and fulfilling life, free from anxiety.

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